Download Biology, Computing, and the History of Molecular Sequencing: by M. García-Sancho PDF
By M. García-Sancho
Sequencing is usually associated with the Human Genome venture and celebrated achievements about the DNA molecule. despite the fact that, the background of this custom contains not just educational biology, but in addition the area of computer-assisted info administration. The booklet uncovers this historical past, qualifying the hype and expectancies round genomics.
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Additional info for Biology, Computing, and the History of Molecular Sequencing: From Proteins to DNA, 1945–2000
Sample text
8 Historians have partially mitigated this effect by placing molecular biology within the context of the development of post-World War II life sciences. , 1998, p. 1). This literature implicitly suggests that all the biological disciplines were transformed according to the parameters of molecular biology (Abir-Am, 1982; Kay, 1993; Olby, 1990; Fox Keller, 2000). Sanger’s early career illustrates that the phenomenon of molecularisation cannot be explained solely within the development of molecular biology.
De Chadarevian argues that contacts with molecular biologists were decisive in Sanger’s shift, and equally, that the Emergence 19 introduction of sequencing into a molecular biology laboratory shaped the emergence of this discipline (de Chadarevian, 1996, 1999). De Chadarevian’s papers thoroughly analyse Sanger’s first protein sequencing methods and their incorporation into the technical repertoire of molecular biology. , 1996, especially pp. 1 In her latest paper, de Chadarevian argues that Sanger’s early protein techniques ‘informed initial attempts at nucleic acid sequencing’, but says little about how the practices and working strategies behind sequencing evolved from proteins to RNA and DNA (de Chadarevian, 1999, quote from p.
The accounts of molecular biologists have been influential not only on lay understandings, but also within academic studies of current science and technology. g. Judson, 1977, 1992; Wills, 1991; Cook-Deegan, 1994; Atkinson, Greenslade and Glasner, 2007). Other biological fields and molecules – even those, such as proteins, which were important for the 46 Emergence development of molecular biology – are obscured by these DNA-centred stories (de Chadarevian, 2002, ch. 8 Historians have partially mitigated this effect by placing molecular biology within the context of the development of post-World War II life sciences.