By Belinda S. Parker, Bedrich L. Eckhardt (auth.), Gurmit Singh, William Orr (eds.)

Patients with complex breast or prostate cancers frequently enhance bone metastases. The significant problems as a result of metastatic bone disorder are discomfort, spinal wire compression, pathologic fractures and bone marrow suppression. enhancing the administration of bone metastases is essential to caliber of lifestyles for sufferers with breast and prostate melanoma.

Advances in figuring out of the molecular mechanisms underlying the pathophysiology of bone metastasis are riding the improvement of latest healing suggestions.

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PCR detection was linear, specific, more sensitive than conventional PCR, and could be used to directly quantitate metastatic burden in bone and soft organs. Attesting to the sensitivity and specificity of the PCR detection strategy, as few as several hundred metastatic MDA-MB-231 cells were detectable in 100 micron segments of paraffin-embedded lung tissue, and only in samples adjacent to sections that scored positive by histological detection (Figure 1). Moreover, the measured real-time PCR metastatic burden in the bone environment displayed a high correlation to the degree of osteolytic damage observed by high resolution X-ray analysis (Figure 2).

Unfortunately, osteosclerotic type of prostate cancer metastasis to bone has been difficult to mimic in animal models. , PC-3, LNCap, PA III) (20, 24, 25). The syngeneic Dunning MAT-LyLu rate prostate cancer model has been argued to be the first described primarily osteoblastic model (26). Human, estrogen dependent breast carcinoma cells, MCF-7 have also been reported to develop osteosclerotic bone metastases after initial bone resorption (21). , MCF-7 and T-47D) is still not clear since, in order to support the growth of these breast cancer cells, it is necessary to give supplementation of estrogen because there are insufficient levels of estrogen in female nude mice.

46. 47. 48. 49. 50. 5l. 52. 53. 54. 55. 56. 57. 58. 59. 60. 61. 62. 63. 64. Choi SJ, Cruz JC, Craig F, Chung H, Devlin RD, Roodman GD, Alsina M. Macrophage inflammatory protein I-alpha is a potential osteoclast stimulatory factor in multiple myeloma. Blood, 96: 671-675,2000. Abe M, Hiura K, Wilde J, Moriyama K, Hashimoto T, Ozaki S, Wakatsuki S, Kosaka M, Kido S, Inoue D, Matsumoto T. Role for macrophage inflammatory protein (MIP)lalpha and MIP-Ibeta in the development of osteolytic lesions in multiple myeloma.

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