Download Brain Dopaminergic Systems: Imaging with Positron by Yves Agid (auth.), J. C. Baron, D. Comar, L. Farde, J. L. PDF
By Yves Agid (auth.), J. C. Baron, D. Comar, L. Farde, J. L. Martinot, B. Mazoyer (eds.)
'....the publication is most precious if you happen to are beginning to learn the mind dopaminergic process and are contemplating puppy as a tool.'Nuclear Medicine 19:9 1992
Read Online or Download Brain Dopaminergic Systems: Imaging with Positron Tomography: Proceedings of a Workshop held in Caen, France within the framework of the European Community Medical and Public Health Research PDF
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Extra info for Brain Dopaminergic Systems: Imaging with Positron Tomography: Proceedings of a Workshop held in Caen, France within the framework of the European Community Medical and Public Health Research
Sample text
And Halldin C. (1986b) Dopamine Dl-receptor binding in the living human brain. , Creese I. (eds) Neurobiology oj central Dldopamine receptors. Plenum, New York, 119. , Hall H. and Halldin C. (1991) llC-SCH 39166, a selective ligand for visualization of dopamine D-l receptor binding in the monkey brain using PET. Psychopharmacology 103, 150. , Yamasaki T. and Tateno Y. (1991) Age-related changes in human Dl dopamine receptors measured by positron emission tomography. Psychopharmacology 103, 41. L.
High AADC activity has also been found in the pineal gland, a tissue rich in melatonin. The cerebral cortex has generally been found to contain very low AADC activity. In tissues such as the cerebellar cortex, cerebral and cerebellar white matter AADC activity has been found very low or abundant. Additionally, in the primate brain the distribution of newly synthesized serotonin and dopamine following administration of the amine precursors 5-hydroxytryptophan and L-DOPA in vivo, correlates closely to the distribution of AADC found in vitro (Lloyd et al.
From a theoretical point of view this is of course misleading. Once the carboxylic group is lost the radiolabel will leave the brain by the following ways: 1. by diffusion of the resulting amine 2. by diffusion or via specific transport systems for the labelled amine metabolites. Until now there has been no attempts to estimate the impact of this efflux on the results obtained from kinetic modelling. However, indirect evidence indicate the unidirectional model being an acceptable approximation.