By Giulia De Falco PhD, Catherine Soprano (auth.), Antonio Giordano MD, PhD, Kenneth J. Soprano PhD (eds.)


The molecular method of illness keeps to yield a major volume of recent information regarding these points of mobile replication that we use to appreciate, hinder, diagnose, and treatment melanoma. In telephone Cycle Inhibitors in melanoma remedy: present ideas, well-known clinicians and investigators evaluate in a understandable and elementary variety the entire most recent information regarding the molecular biology of cell-cycle keep watch over and show its medical relevance to knowing neoplastic ailments. subject matters variety from Cdk inhibitors and phone cycle regulators to the prognostic worth of p27 and tumor-suppressor genes as diagnostic instruments. genuine case stories express how the recent molecular knowing has produced such medicines as Flavopiridol and Sulindac.
up to date and richly instructive, cellphone Cycle Inhibitors in melanoma treatment: present techniques brings the entire fresh serious learn findings to undergo on scientific perform, and obviously indicates their strong impression at the diagnostics, prognostics, and therapeutics of melanoma, AIDS, and cardiovascular disease.

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Biochim Biophys Acta 1998;l377:M61-M70. 23. Pagano M, Tarn SW, Theodoras AM, Beer-Romero P, DeI Sal G, Chau V, et al. Role ofthe ubiquitin-proteasome pathway in regulating abundance of the cyc1in-dependent kinase inhibitor p27. Science 1995;269:682-685. 24. PivaR, Cancelli I, CavallaP, Bortolotto S, DominguezJ, DraettaGF, Schiffer D. Proteasomedependent degradation of p27lkipl in gliomas. J Neuropathol Exp NeuroI1999;58:691-696. 25. Agus DB, Cordon-Cardo C, Fox W, Drobnjak M, Koff A, Golde D W, Scher HI.

Lloyd RV, Erickson LA, Jin L, Kulig E, Qian X, Cheville JC, Scheithauer BW. p27kipl: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers. Am J PathoI1999;154:313-323. 3. Sgambato A, Cittadini A, Faraglia B, Weinstein IB. Multiple functions ofp27(Kipl) and its alterations in tumor cells: a review. J Cell PhysioI2000;183: 18-27. 4. Slingerland J, Pagano M. Regulation of the cdk inhibitor p27 and its deregulation in cancer. J Cell PhysioI2000;183:1O-17.

70. Pierce AM, Schneider-Broussard R, Gimenez-Conti IB, Russell JL, Conti CJ, and Johnson DG. E2Fl has both oncogenic and tumor-suppressive properties in a transgenic model. Mol Cell BioI1999;19:6408-6414. 71. Robles AI, Larcher F, Whalin RB, Murillas R, Richie E, Gimenez-Conti IB, et al. Expression of cyclin D 1 in epithelial tissues of transgenic mice results in epidermal hyperproliferation and severe thymic hyperplasia. Proc Natl Acad Sei USA 1996;93:7634-7638. 72. Rodriguez-Puebla ML, LaCava M, Conti CJ.

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