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Antimicrobial Agents and Chemotherapy 1982, 21: 604-607. Notes In Vitro Activity of Ciprofloxacin Against Clinical Isolates of Chlamydia trachomatis H. Meier-Ewert G. Weil G. Millott In the search for antimicrobic agents to combat sexually transmitted diseases, the new compound ciprofloxacin has raised great expectations. The effectiveness of this drug against a number of relevant bacteria has already been demonstrated in several publications (1, 2). It therefore seemed of particular interest to investigate the activity of ciprofloxacin against Chlamydia trachomatis, an important human genital pathogen.

After 4 h of such dilution and periodic "micturition", exposure to the antibacterial agent commenced. By using a gradient-forming device (MixoGrad; Gilson Medical Electronics, Villiers Ie Bel, France), the concentration of drug in the broth entering the system was allowed to reach a peak concentration over 4 h. The peak concentration was maintained for 2 h after which the concentration of drug fell once more over a 6 h period (12 h of drug exposure in all). The response of the culture to the antibacterial agent was continuously monitored photometrically 27 Activity of ciprofloxacin and the efficacy of the drug was assessed in terms of the time elapsed from the initial exposure until the opacity of the culture reattained a level of 50 % of maximum.

European Journal of Clinical Microbiology 1983, 2: 225-276. 2. , Andrews, J. , Edwards, L. : In vitro activity of Bay 09867, a new quinolone derivative, compared with those of other antimicrobial agents. Antimicrobial Agents and Chemotherapy 1983, 23: 559564. 3. Fass, R. : In vitro activity of ciprofloxacin (Bay 09867). Antimicrobial Agents and Chemotherapy 1983, 24: 568-574. 4. : An in vitro model of the urinary bladder. Journal of Antimicrobial Chemotherapy 1978, 4: 113-120. 5. : Factors governing the emergence of resistance to nalidixic acid in the treatment of urinary tract infection.

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