By Mary Moyer (Eds.)

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Cancer Res. 38, 1 8 9 9 - 1 9 0 5 . Dukes, C. E. (1932). The classification of cancer of the rectum. J. Pathol. Bacteriol. 35, 3 2 3 - 3 3 2 . Elsayed, A. , and Shamsuddin, Α. Κ. M. (1986). Agglutinin as a marker for preneoplastic and neoplastic changes in the human and rat colon. Proc. Am. Assoc. Cancer Res. 27, 2 0 1 . Falterman, K. , Hill, C. B . , Markey, J. C , Fox, J. , Jr. (1974). Cancer of the colon, rectum and anus—A review of 2313 cases. Cancer 34, 9 5 1 - 9 5 9 . Fenoglio, C. , and Lane, N.

In the cecum, which has a large capacity, these neoplasms may attain a very large size without causing any sign or symptom of obstruction. The fluidity of cecal contents also contributes to the silent nature of these neoplasms. The flat infiltrative type does not protrude into the intestinal lumen; it infiltrates through the entire circumference of the intestinal wall in an annular fashion. This causes considerable narrowing of the lumen of the intestine. Coupled with the fact that the feces are more formed in the distal intestine, this type of neoplasm gives rise to early symptoms of obstruction.

1986). Furthermore, we have discovered that a variety of precancerous lesions of the lung, esophagus, and large intestine express CEA in tissues (A. M. Shamsuddin and D. M. Purnell, unpublished observation). These findings may explain why, for example, smokers (with squamous metaplasia of the bronchus) have elevated CEA in the blood. Further studies on CEA are thus needed, as the CEA story is far from complete. It has been demonstrated that the mucus in cancer and precancer tissue is abnormal (Shamsuddin and Trump, 1981b).

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