By Syed K. Mohsin
The Frozen part Library sequence offers concise, trouble-free, website particular handbooks which are good illustrated and spotlight the pitfalls, artifacts and differential analysis concerns that come up within the moved quickly frozen part situation.
Frozen part Library: Breast offers a simple reference and notebook concerning the nuances of correctly dealing with breast specimens in a manner that meets the more and more advanced setting of breast pathology. the professionals and cons of frozen part as opposed to use of contact imprint in addition to similar caliber insurance specifications are addressed. different much less universal makes use of of intraoperative assessment, equivalent to prognosis and margin evaluate are defined. the amount comprises urged guidance for evaluate and documentation of particular gross pathologic positive aspects, at the side of radiological imaging. ideas and protocols for such examinations are illustrated. the quantity closes with an outline of the newly released directions for dealing with quite a few breast specimens, that are meant for use for review of predictive factors.
Syed ok. Mohsin, M.D. is the top of Breast Pathology and scientific Director, Immunohistochemistry, Riverside Methodist health center, Columbus, OH
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Additional info for Frozen Section Library: Breast
34 Diff-quik stained touch imprint from a positive SLN. This airdried preparation is well prepared. The background shows some red cells. It is easy to identify a cluster of malignant epithelial cells. 35 Touch imprint of a negative SLN. This is an alcohol fixed touch imprint of the SLN, stained with H&E. The background is relatively clear with a few red blood cells. The lymphocytes are easy to recognize. No epithelial cells are seen. 36 Alcohol fixed touch imprint of a positive SLN. In this preparation, there is an equal proportion of single and clusters of malignant epithelial cells.
There are a few possible clusters of epithelial cells, which need more evaluation. 21 Alcohol-fixed touch imprint for surgical margin evaluation. This touch imprint for margin is fixed in alcohol and a rapid H&E stain is done. The background is clear and there is only a small amount of fat on the slide, consistent with a negative margin. 22 Typical features of touch imprint from a negative margin. Intermediate power view of an alcohol-fixed touch imprint. Besides clear background and small amount of fat, there is a small group of epithelial cells.
2. There is an inflamed normal breast unit at the inked margin. 4 Negative margin on frozen section. The tissue is fragmented and ink has seeped into the tissue. However, the histologic features are easy to read and show benign breast epithelium and stroma. 5 Optimal frozen section due to fibrous tissue at the margin. Due to less fat in the tissue, an optimal section can be prepared and it shows negative surgical margin. 6 Close but negative margin on frozen section. The inked and cauterized margin is present in the left upper corner.