Download Human Gene Therapy: Current Opportunities and Future Trends by G. J. Nabel (auth.), Gabor M. Rubanyi, Seppo Ylä-Herttuala PDF
By G. J. Nabel (auth.), Gabor M. Rubanyi, Seppo Ylä-Herttuala (eds.)
Advances in genetics, molecular biology and gene supply applied sciences lately have bring about new gene treatment innovations to regard various ailments. This publication offers a finished evaluation of the current prestige and destiny instructions of gene supply structures and healing options for the scientific program of gene treatment in melanoma, cardiovascular and vital fearful method illnesses. Stem cell-based cures and gene expression regulatory platforms, as novel platform applied sciences for varied gene remedy functions also are mentioned. top specialists supply very good overviews of simple molecular features and scientific purposes during this new rising biomedical field.
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High Expression in Hepatocytes from Intravascular Delivery of Plasmid DNA . . . . . . . . . . . . . . . . . . . . 5 Rapid Injection of Plasmid DNA into the Tail Vein of Rodents . . 6 Intravascular Delivery of Plasmid DNA for Delivery to Limb Skeletal Muscles . . . . . . . . . . . . . . . . . 7 Sustained Expression Requires Special Plasmid Constructs . . . 8 An Active Cellular Mechanism May Enable Naked Plasmid DNA Uptake . . . . . . . . . . . . .
1 Therapeutic Angiogenesis . . . . . . . . . . . . . . . . . 2 Mechanisms of Therapeutic Angiogenesis . . . . . . . . . . 3 Clinical Trials . . . . . . . . . . . . . . . . . . . . . 4 Conclusions and Future Directions . . . . . . . . . . . . . 5 References . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Introduction Myocardial ischaemia and peripheral vascular disease are very significant clinical problems in the elderly population.
Lidocaine) distal to the tourniquet. Surgery in humans can be performed for a couple of hours using this anesthetic procedure. Similarly, histologic analyses of the rat, dog, and rhesus muscles in our experiments indicated that the ischemia did not cause myofiber damage. Besides gene therapy for muscle defects, it appears worthwhile to evaluate this method for delivery of angiogenic genes for the treatment of ischemia. Delivery is not limited to skeletal muscle, but can also target cardiac muscle (retrograde delivery via standard angioplasty catheters) and can thus potentially be used for treating heart ischemia (Herweijer et al.