By Elizabeth Roboz Einstein (auth.), Jorma Palo (eds.)
A satellite tv for pc symposium entitled "Myelination and Demyelination: fresh Chemical Advances" was once held in Helsinki from August 29 to 31, 1977, after the 6th foreign assembly of the overseas Society for Neurochemistry (ISN) in Copenhagen. Myelin is a fearful tissue constitution that's most fitted as an issue of biochemical research. you can still isolate in a hugely purified shape, is quite sturdy even after dying, and is af fected by way of a number of neurological and different ailments. Its lesions are fairly very important within the learn of a number of sclerosis, a disorder that's rather conventional in Finland and has as a result been of curiosity to an exceptional many Finnish scientists. the 1st half this publication is anxious with the biochemical composition and molecular association of myelin, the second one part with the experimental and scientific elements of demyelination. The reviews given after all of the displays on the symposium weren't recorded as such, yet each one writer used to be asked to change his or her paper hence. The enhancing and book of this publication wouldn't have been attainable with out the wonderful efforts and co-operation of my spouse, Mrs. L.-M. Palo, appearing as common secretary and later as editorial secretary of the symposium. As Organizing Committee Chairman, i'd additionally wish to thank the contributors of the Committee: Dr. M. Haltia, Dr. E. Kivalo, Dr. T. Kosunen, Dr. M. Panelius, and particularly Dr.
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Additional info for Myelination and Demyelination
It seems likely that ~elin precursors are synthesized by the endoplasmic reticulum and that their cisternae, together with intermediary-fragments of the myelin formative cell membrane, can be isolated in the microsomal fraction from developing brain. in parallel with ~elin synthesis (2). Apparently the high molecular weight (Wolfgram) protein is synthesized on the endoplasmic reticulum of the formative cell and then found on the outer myelin membrane or interperiod line (Mandel, P. , private communication).
12. 13. , Phospholipase A1 and A activities of neuronal and glial cells of the rabbit brain, ~oppe Seyler's Z. Physiol. Chern. 354 (1973) 729-736. , Phospholipid metabolism in experimental allergic encephalomyelitis: Activity of mitochondrial phospholipase A2 of rat brain towards specifically labelled 1,2-diacyl-, 1-alk-1'-enyl-2-acyl- and 1-alkyl2-acyl-sn-glycero-)-phosphorylcholine, J. Neurochem. 23 (1974) 745-750. , Subcellular distribution and kinetic properties of rat brain phospholipases A1 and A2 .
MYelin lipid synthesis still continues after inhibition of protein formation (4), suggesting that, at least, sulphatide, phosphatidyl choline and phosphatidyl ethanolamine do not enter the myelin membrane synchronously with newly-formed protein. The subsequent metabolism of the sheath is still a matter of debate (see for example 5, 9, 14). The oligodendroglial cell and myelination. It has been concluded that oligodendroglial cells are the site of synthesis of myelin, although there is only a little evidence that the glial membrane and ~elin are chemically identical.