By D. R. Elmaleh, E. E. van der Wall, E. Livni (auth.), E. E. van der Wall (eds.)
F.J.Th. WACKERS Metabolic imaging: the way forward for cardiovascular nuclear imaging? on the grounds that cardiovascular nuclear imaging emerged as a brand new subspecialty within the mid-1970s, the sector has undergone an explosive progress. Radionuclide innovations turned quite simply well-known as very important new diagnostic aids within the armamentarium of the medical heart specialist. in the beginning, cardiovascular nuclear imaging all in favour of static myocardial imaging utilizing both thallium-201 or technetium-99m-pyrophosphate for diagnosing acute myocardial infarction. presently thereafter, multigated equilibrium radionuclide angiocardiography turned the main widespread noninvasive procedure for assessing cardiac functionality. moreover, realization and scientific software shifted in the direction of using radionuclide ideas along side workout trying out, both with thallium-20 1 myocardial perfusion imaging or technetium-99m left ventricular functionality experiences. the way forward for cardiovascular nuclear imaging seemed intriguing and promising. even if, round 1980 pessimists expected the untimely dying of cardiovascular nuclear imaging with the creation of electronic subtraction angiography and nuclear magnetic resonance imaging. those doomsayers were confirmed mistaken: in 1985 cardiovascular nuclear imaging is prospering and, in lots of facilities, even increasing. even though electronic substraction angiography and magnetic resonance imaging supplied beautiful anatomic aspect, for functional overview of sufferers with ischemic middle ailment - within the Coronary Care Unit or workout laboratory - nuclear options extra practical.
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Extra resources for Noninvasive Imaging of Cardiac Metabolism: Single Photon Scintigraphy, Positron Emission Tomography and Nuclear Magnetic Resonance
Table 5. 2 Table 6. 0 25 Figure 3. Heart images obtained from human normal volunteers after the intravenous admini- stration of (A): 123I-(p-iodophenyl)-3-(R,S)-tctradccanoic acid (IBMPT A) (2mCi); (B): (l_llC)betamethylheptadecanoic acid (3 mCi). The positron camera, PC-II was used to collect the 20 images; (C): TI-201 and 123I-IBMPT A in the same volunteer (immediate scans post-injection). incorporation of both BMHA and palmitic acid into the same metabolic compartment. However, the data suggest that the fate of the modified fatty acid in blood and heart should be considered when we use these analogs.
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The organic phase of the extract was analyzed by TLC for triglycerides (TG), diglycerides (DG), free fatty acids (FFA), monoglycerides (MG) and polar lipids (PL) (Table 5). The distribution of the label between the organic (0), aqueous (A) and insoluble tissue (T) of the heart was measured (Table 6). The data in Tables 5 en 6 show Table 4. 11 " 12 Rats: all other time points 6 rats/point. Table 5. 2 Table 6. 0 25 Figure 3. Heart images obtained from human normal volunteers after the intravenous admini- stration of (A): 123I-(p-iodophenyl)-3-(R,S)-tctradccanoic acid (IBMPT A) (2mCi); (B): (l_llC)betamethylheptadecanoic acid (3 mCi).