By T. Loop, H. L. Pahl (auth.), Rudi Beyaert (eds.)

Seventeen years after its preliminary description, nuclear factor-KB (NF-KB) endures as probably the most studied transcription elements. NF-KB has attracted common curiosity according to the diversity of stimuli that turn on it, the various genes and bio­ logical responses that it controls, the notable evolutionary conservation of struc­ ture and serve as between species, and its involvement in a number of human ailments. The biochemical foundation wherein a number of stimuli converge to turn on NF-KB has been mostly elucidated in the course of contemporary years. whereas first stumbled on as a key regulatory issue of the immune procedure, NF-KB is now well-known as an incredible participant within the functioning of many organs and mobile varieties. the continued exam of NF-KB signaling has published its ever increasing position in immune and inflammatory responses, but in addition in melanoma and improvement. consequently, quite a few efforts are underway to strengthen secure inhibitors of NF-KB for use within the remedy of either persistent and acute disorder occasions. the current ebook is the 1st to study and synthesize our wisdom of this attention-grabbing transcription issue. As such, the alternative of matters to check was once daunting. To set the level, an introductory bankruptcy on activators and objective genes, in addition to the position they play in numerous responses, has been included.

Show description

Read or Download Nuclear Factor кB: Regulation and Role in Disease PDF

Similar nuclear books

Heat Transfer and Fluid Flow in Nuclear Systems

Warmth move and Fluid in circulate Nuclear structures discusses subject matters that bridge the distance among the elemental rules and the designed practices. The publication is made from six chapters that disguise research of the predicting thermal-hydraulics functionality of huge nuclear reactors and linked heat-exchangers or steam turbines of varied nuclear structures.

The Nuclear Receptor Facts: Book

The FactsBook sequence has demonstrated itself because the top resource of simply available and actual proof approximately protein teams. They use an easy-to-follow structure and are researched and compiled by way of specialists within the box. This Factsbook is dedicated to nuclear receptors. the 1st part provides an creation and describes the mode of motion of the receptors in most cases.

Fukushima: Impacts and Implications

The Fukushima nuclear catastrophe in March 2011 led Japan, and lots of different nations, to alter their strength rules. David Elliott stories the catastrophe and its worldwide implications, asking no matter if, regardless of persisted backing by way of a few governments, the transforming into competition to nuclear strength skill the tip of the worldwide nuclear renaissance.

Additional info for Nuclear Factor кB: Regulation and Role in Disease

Example text

Cell. BioI. 17: 3202-3209. Meyer M, Caseimann WH, Schluter V, Schreck R, Hofschneider PH & Baeuerle PA (1992) Hepatitis B virus transactivator MHBst: activation of NF-KB, selective inhibition by antioxidants and integral membrane localization. EMBO J. 11: 2991-3001. Miagkov AV, Kovalenko DV, Brown CE, Didsbury JR, Cogswell JP, Stimpson SA, Baldwin AS & Makarov SS (1998) NF-KB activation provides the potential link between inflammation and hyperplasia in the arthritic joint. Proc. Natl. Acad. Sci.

Chan H, Bartos DP & Owen-Schaub LB (1999) Activation-dependent transcriptional regulation of the human Fas promoter requires NF-KB p50-p65 recruitment. Mol. Cell. BioI. 19: 2098-2108. Chen C, Edelstein LC & Gelinas C (2000) The Rel/NF-KB family directly activates expression of the apoptosis inhibitor BcI-x L • Mol. Cell. BioI. 20: 2687-2695. Chen CD & Sawyers CL (2002) NF-KB activates prostate-specific antigen expression and is upregulated in androgen-independent prostate cancer. Mol. Cell. BioI.

Natl. Acad. Sci. USA 95: 13859-13864. Miettinen M, Lehtonen A, Julkunen I & Matikainen S (2000) Lactobacilli and Streptococci activate RELlNF-KB TRANSCRIPTION FACTORS 37 NF-KB and STAT signaling pathways in human macrophages. J. Immunol. 161: 3733-3740. Miller EJ, Cohen AB, Nagao S, Griffith D, Maunder RI, Martin TR, Weiner-Kronish JP, Sticherling M, Christophers E & Matthay MA (1992) Elevated levels of NAP-llinterleukin-8 are present in the airspaces of patients with the adult respiratory distress syndrome and are associated with increased mortality.

Download PDF sample

Rated 4.98 of 5 – based on 36 votes