By MICHAEL H.RUBINSTEIN, James I. Wells, Michael H. Rubinstein
Extends the strategies of quantity 1 to incorporate drug houses, layout and optimization, coating and the impact of nutrition and pharmacokinetics. This quantity additionally displays the transforming into curiosity in biodegradable polymers in oral and topical formulations and using sterile implants.
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Extra info for Pharmaceutical Technology. Controlled Drug Release,
6 produces minimum release rates from the tablets. 3. g. 7 is enough to produce burst release. However, the integrity is still maintained in disintegration studies for 53 min. This emphasizes the importance of the initial gelling of the HPMC to protect tablet integrity. When examining the dissolution rate of drugs from HPMC matrices it would seem that electrolytes added to the dissolution medium, even in small amounts, will modify the dissolution rate. It could well be that when studying the release at different pH values the changes in rates seen are not entirely due to changes in pH but are also due to the buffers used to produce that pH.
As the electrolyte concentration further increased the release rates similarly increased until a ‘burst’ release occurred. These initial decreases in release rates were probably coincident with a decrease in polymer solubility, in that as the ionic strength of the dissolution medium is increased the cloud point is lowered towards 37°C. It may be seen from Table 5 that minimum release rates occurred when the cloud point was ~37°C. At this point the pore tortuosity within the matrix structure should also be at a maximum.
The wet granulation release profile exhibits a marked sigmoid aspect owing to the high β value.