Download Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell by Denis Corbeil Ph.D., Jana Karbanová, Christine A. Fargeas, PDF
By Denis Corbeil Ph.D., Jana Karbanová, Christine A. Fargeas, József Jászai (auth.), Denis Corbeil (eds.)
Prominin-1 or another way referred to as CD133 is a glycoprotein that's found in people and mice. because the first description of prominin in 1997, in mouse neuroepithelial cells and in human hematopoietic stem cells as AC133 antigen, this molecule has aroused a wide curiosity specially, as a stem cellphone marker, that gave upward thrust to an ever starting to be physique of courses and extra lately its expression in melanoma stem cells. Controversies as to its function as a melanoma stem and its detection in several types, in addition to its use as a prognostic marker have emerged. but, past its use as a stem mobile and melanoma stem cellphone marker, prominin-1/CD133 screens special organic gains and looks of value in different techniques like for instance in retinal biogenesis. certainly, this five-transmembrane plasma membrane glycoprotein, which marks membrane protrusions is linked to a number of crucial approaches like telephone polarity, uneven telephone department and membrane home improvement. we recommend to study present wisdom approximately this fascinating molecule and current pertinent details to figure out the organic function of prominins and verify their value in drugs and melanoma study. the first viewers for this booklet is geared in the direction of scientists and researchers with curiosity in melanoma stem cells, stem cells, phone biology, neurobiology, and regenerative medicine.
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Additional info for Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology
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73% and 60%, respectively, between human and mouse) [5]. , 17% amino acid identity compared to 26% overall identity between human prominin-1 and prominin-2; see Fig. 1) [6, 10]. Moreover this domain is encoded by only two exons, whereas up to four may be involved in the case of prominin-1. , unpublished data). , Meleagris gallopavo, Gallus gallus breed, Anolis carolinensis, Chrysemys picta) (not shown) and more divergent in the amphibian Xenopus laevis [11]. This sequence conservation suggests that the cytoplasmic tail of prominin-2 is likely important for the function of the molecule.
What are the extracellular and cytoplasmic protein partner(s) that interact with prominins and their splice variants? Clinically, prominin-1 has been considered a useful stem cell marker and promising target for the development of new cancer therapies. The identification of human retinal degenerations directly associated with mutations in the PROM1 gene makes it a potential candidate for gene replacement therapy. Prominin-1 and the small prominin-1-containing membrane vesicles that are released in various body fluids are of particular medical interest.
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