Download Structure and Function of Major and Minor Small Nuclear by Ram Reddy, Harris Busch (auth.), Prof. Dr. Max L. Birnstiel PDF
By Ram Reddy, Harris Busch (auth.), Prof. Dr. Max L. Birnstiel (eds.)
In the earlier decade a finest tale of the position performed by way of the small nuclear RNPs, catalysts in RNA processing, has spread out. Early investigations of the constitution of those debris gave upward thrust to hypotheses in their features. As defined during this e-book, those were proven or are being established through biochemical ex perimentation and such a lot lately by means of the robust means of genetic research. either biochemical and genetical techniques also will make certain to what measure, and the way, snRNPs and their cofactors perform the differential expression of genes. because the info emerge and the variety of snRNP species raises means past the six before everything pointed out, one feels on the threshold of even higher issues to come back. The e-book covers many ends up in probably the most speedily increasing fields of molecular biology. accordingly on my own the professional may perhaps notice a few omissions and shortcomings. i am hoping they are going to be few. rather than proposing a collation of convention reviews with a lot overlap among them, this e-book has been written specifically for the aim of surveying the literature as much as early 1987 within the snRNP box in a coherent demeanour, all of the seven chapters having been produced by way of connoisseurs in their box. whereas no longer every snRNP tale will be coated in one of these publication, i'm hoping that it'll supply stress-free and stimulating reading.
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Additional resources for Structure and Function of Major and Minor Small Nuclear Ribonucleoprotein Particles
Example text
3 Organization Within snRNA Gene Loci In the case of the human V1 genes, restriction mapping and direct nucleotide sequence analyses of ten independent isolates revealed that the sequences flanking the V 1 coding regions are identical for several hundred base pairs upstream (Manser and Gesteland 1982; Lund and Dahlberg 1984; Bernstein et al. 1985) and are surprisingly homologous over large distances (Manser and Gesteland 1982; Htun et al. 1984); surprisingly, the homologous sequences extend for more than 20 kb in both directions (Bernstein et al.
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J BioI Chem 255:8901-8906 Epstein P, Reddy R, Busch H (1981) Site-specific cleavage by T1 RNase of U1 RNA in U1 ribonucleoprotein particles. Proc Natl Acad Sci USA 78:1562-1566 Epstein P, Reddy R, Busch H (1984) Multiple states of U3 RNA in Novikoff hepatoma cells. Biochemistry 23:5421- 5425 Forbes D, Kirschner M, Caput D, Dahlberg J, Lund E (1984) Differential expression of mUltiple U1 small nuclear RNAs in oocytes and embryos of Xenopus laevis. Cell 38:681-689 Francoeur AM, Gritzmacher CA, Peebles CL, Reese RT, Thn EM (1985) Synthesis of small nuclear ribonucleoprotein particles by the malarial parasite Plasmodium Jalciparum.