By Ray S. Snider (auth.), Irving S. Cooper, Manuel Riklan, Ray S. Snider (eds.)

In cats anesthetized calmly with pentobarbital or alpha-chloralose, electric stimulation of the paramedian lobule of cerebellum ended in a metamorphosis of EEG development. ahead of stimulation the trend consisted of h igh-ampl itude sluggish waves with superimposed low-ampl itude quickly task. additionally, the EEGs of animals anesthetized with chloralose confirmed "chloralose spikes". instantly following short cerebellar stimulation the sluggish wave job and spikes disappeared, leaving purely low-voltage speedy task. The impact was once so much said within the contralateral leads from the rostral parts of the cerebrum. examine of the parameters premier in evoking this influence printed that stimulation frequency, teach period, and possibly pulse period affected the length of suppression in a sigmoid style, with inflection issues at nearly ninety Hz, 2.5 sec, and 1 msec, respectively. Above threshold values, stimulation cur­ hire confirmed an nearly linear courting to length of EEG sup­ pression. The after-discharge as a result of focal electric stimulation of the cerebral cortex will be shortened by means of electric stimulation of the para­ median lobule. The impact used to be primarily a similar whilst cerebellar stim­ ulation preceded, happened in the course of, or the cerebral cortical stim­ ulation. the nice variability of the after-discharge caused by cerebral cortical stimulation in addition to the variety of the consequences of cerebellar stimulation made it impractical to check systematically the parameters op­ timal for shorten ing after-discharge. this type of research wi II require use of an wide awake, ideally partly confined animal with electrodes chronically implanted.

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Reprinted from Babb et al. (1974) with permission from the author and publisher). G> » .. IV~~"--+---i 183 LT. V HIPPO "" '" LT FASTIGIAL RT. V HIPPO 1:10 PM RT VA. IA RT. SOM CTX LT. SOM CTX 100 • 200 •••••• TIME SINCE FIRST SE IZURE ONSET ( M IN,) 20 " ' 200 ...... . :'" • :'.. . ,....... '' ••' 100 I ~O , 2l> • . ' . ZOO >bo 0 200 ~ . # .. CAT ZC : roo 500 . . 0 200 .. :,,-.... ; ••.. ,-t,,', .. 100 180, ::""!. ,':::'. , :.. :.......... ,l zix- ¥~... 'W: .. : ,. , . 1 •• - . ~ .. ° .. 4 '01 20 ' : 2A .

Eventually these after-discharges developed into the tonic phase of a clinical seizure which was clearly indicated by bilateral spread to other brain structures (Fig. lA) and by behaviors such as "staring", head-turning (tonic phase) and ear twitching, eye blinking, and masticating {clonic phase as indicated in Fig. 1B}. The average duration of seizures in different animals varied widely but was somewhat reliable for a given animal for periods as long as two hours. Beyond that, se izure severity and its duration in seconds increased with time.

HIPPO.. STIMULUS LT FASTIGIAL RT V H P I PO. RT SCM. CTX. &:, RT SCM CTX RT V. A. ~ rr- }> o Z ~ () :::r: "'tJ o Z }> rr- m :::r: ~ ~ (,) . }> 0:1 0:1 . ~ r- -I 0- CEREBELLAR INFLUENCES ON THE HIPPOCAMPUS Ik. 47 LT SOM. CTX RT SOM. CTX STIMULUS RT. V. HIPPO LTV. HIPPO L1 SOM. CTX. CTX. F RTV. HIPPO LT V. HIPPO Fig. 6. /kg. ). The overall impression gained from these phase one stimulation procedures was that vermis, fastigial, and bulbar reticular areas exert some degree of inhibition on hippocampus.

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