By Morris Rockstein (Eds.)

Theoretical of points of Aging

summary: Theoretical of points of getting older

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Creating pervasive cross linked cages or network impeding intracellular transport and thereby disturbing the various functions of the immune system. This type of obstruction and its genesis have already been discussed (figure 4 ) . b. Causing crosslinkages involving essential molecules thus hampering their function. c. Causing destruction of sites in DNA which govern immunologic functions (as shown in figure 2 ) . A penetrating study of these aspects would seem to be indicated. I shall take this opportunity to answer a few questions raised by Dr.

1973). Science 182, 1357. , Adler, W. H. and Smith, R. T. (1971). J. Exp. Med. 133, 63. Thomsen, 0. and Kettel, K. (1929). Z. Immunitatsforsen. 63, 67. Waldorf, D. , Wilkens, R. F. and Decker, J. C. (1968). 1* Am* Med. Assoc. 203, 111. Walford, R. L. (1969). " Ch. IV, Munksgaard, Copenhagen. 42 CROSSLINKAGE AND THE AGING PROCESS Johan Bjorksten Bjorksten Research Foundation Madison, Wisconsin 53701 Of all chemical reactions, crosslinkage is the one by which the smallest amount of interference can produce the greatest amount of damage.

The animals are now 19 months old. One of the controls is dead, while the other is greyer, slower and fatter than the animals which have received the injections. The animal which has received the greatest amount of enzyme is the least grey and weighs less than the control. This was not true at the beginning of the experiment. Of course, it is impossible to form any firm conclu­ sion from these few animals in a test originally intended only to check for toxicity, but the results are not dis­ couraging.

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