By Peter K. Jeffery (auth.), D. Olivieri, P. J. Barnes, S. S. Hurd, G. C. Folco (eds.)

From the 19-29 could 1991 the NATO ASI path PAsthma remedy: A P Multidisciplinary procedure used to be held in Erice, at the rocky North West Coast of Sicily, dealing with the traditional Phoenician shore of the African Continent. Sixty NATO subsidized individuals coming back from many alternative eu nations - Nato participants and non - attended the path. certified researchers from Europe and the USA held broad lectures, brief conferences and small casual staff discussions. Erice is a paranormal position which attracts jointly humans from varied backgrounds and cultures below her Mediterrean allure, recreating the traditional Greek openair dialogue surroundings. And so, in the course of the 10 days amassing, the huge willingness of the senior investigators and the laudable enthusiasm of the more youthful members was once inspired. the entire latest findings within the biology and the pharmacology of bronchial asthma have been mentioned, at the start at the back of closed doorways, to be unhurriedly endured alongside the alley methods of the "Cittadella della Scienza" , in Erice's small eating places, and on her abandoned shores. The texts accumulated listed below are testimony to the top of the range of the investigators contributions in addition to their a long way achieving pursuits. i believe Director of one of these direction will be adequatly happy by means of simply contemplating the passion and excessive point involvement of each player. He couldn't were extra happy after having thought of the lawsuits summerizing the clinical content material of the meeting.

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90. G. S. G. JL Pharmacol 102:79-84 (1991). 91. A. Haggi and A. Meli, The sensory efferent function of capsaicin sensitive sensory nerves, Gen Pharmacol 19:1-43 (1988). 92. J. Barnes, Neurogenic inflammation in airways modulation, Arch Int Pbarmacodyn 303:67-82 (1990). 93. J. Barnes, Asthma as an axon reflex, Lancet i:242-245 (1986). 94. W. S. ~. Cuss, and P. J. m. Rev Respir Dis 135:176-180 (1987). 46 and its 95. P. K. G. G. Baker, Bradykinin stimulates afferent vagal C-fibres in intrapulmonary airways of dogs, J Appl Physiol 48:511-517 (1980).

Bradykinin is a potent activator of bronchial C-fibres in dogs,95 and releases sensory neuropeptides from perfused rodent lungs. 37 In guinea pigs bradykinin instilled into the airways causes bronchoconstriction which is reduced significantly by a cholinergic antagonist (as in asthmatic patients 94 ), and also by capsaicin pretreatment. 96 This indicates that bradykinin activates sensory nerves in the airways and that part of the bronchoconstrictor response is mediated by release of constrictor peptides from capsaicin-sensitive nerves.

Kimura, U. KATSUHATA, and T. Takishima, Effect of nonadrenergic, noncholinergic inhibitory nerve stimulation on the allergic reaction in cat airways, A:L.. Rev. Respir. Dis. 141:29-32 (1990). 30. Yo Yiangou, V. A. Spokes, H. R. R. Bloom, Isolation, characterization, and pharmacological actions of peptide histidine valine 42, a novel prepro-vasoactive intestinal peptide derived peptide, J BioI Che. 262:14010-14013 (1987). 31. R. S. Dixon, Y. R. W. Ind, Effect of peptide histidine valine on cardiovascular and respiratory funtion in normal sUbjects, Thorax 43:750-755 (1988).

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