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By Professor Dr. Günter Burg, Professor Dr. Dr. h.c. Otto Braun-Falco (auth.)
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However, fixation of EAC complex occurs in about 33 % of cutaneous immunocytomas. Intracytoplasmic immunoglobulin may be found in ascending amounts in immunoblasts and plasmablasts, and is always found in plasma cells [424]. t> Above left and right : Typical Marschalk6 plasma cells in a lymphoplasmacytic immunocytoma of the skin. H & E, x 700 (left), x 950 (right) t> Below left and right: Somewhat pleomorphic and binucleated plasma cells in polymorphie light eruption of the skin. 7 Lymphoplasmacytoid Cells Lymphoplasmacytoid cells must be classified between lymphocytes and plasma cells.
This is an expression of a dysfunction of the secretory mechanism in these cells. C> Above: Lymphoplasmacytoid immunocytoma of the skin showing morphological fea- tures intermediate between lymphocytes and plasma cells. Some immunoblasts and typical Marschalk6 plasma cells are also present. H & E, x 1,000 C> Below left and right: Lymphoplasmacytoid immunocytoma of the skin. Many of the cells show intranuclear globular inclusions (l) even with H & E stain (left) , and these inclusions are better seen with the PAS stain (right).
M, macrophage. x 11,100 [> Below: Medium-sized lymphocyte in alesion of a cutaneous B celllymphoma (ultrathin section). The cell is larger than an average lymphocyte but sm aller than an immunoblast, the nuc1eus being mostly euchromatic with a small nuc1eolus (n). The moderately abundant cytoplasm contains only a few organelles, such as ribosomes, vesic1es, and mitochondria (m). 4 Large Noncleaved Cells of Follicle Centers (Centroblasts) Synonyms: germinoblasts [422]; large lymphoid cells [246, 570] Nonc1eaved cells of follic1e centers [449] are also found in germinal centers.