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By Mehmet Gunduz; Esra Gunduz
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CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme. Curr Drug Metab, Vol. 7: 598-610. , Havlioglu, N. and Sandell, L. J. (2010). Type IIB procollagen NH(2)-propeptide induces death of tumor cells via interaction with integrins alpha(V)beta(3) and alpha(V)beta(5). J Biol Chem, Vol. 27: 20806-20817. Yuhas, J. , Tarleton, A. E. and Molzen, K. B. (1978). Multicellular tumor spheroid formation by breast cancer cells isolated from different sites. Cancer Res, Vol. 8: 2486-2491.
Furthermore, in humans, the immune system plays an important role in the fight against tumour, whereas in xenografts models the immune system is totally absent. The xenograft model has some limitations but is the most accomplished of all models because it takes into account the complexity of the organism. Besides the xenografts, there are also murine models which can develop tumours spontaneously or under the influence of inducing compounds (Russo & Russo 1996). Although the achievement of these models is easy, their use is largely debated because of their relevance to the clinical situation.
Breast cancer cell lines: friend or foe? Breast Cancer Research, Vol. 2: 89-95. , Olive, M. and Reeves, W. , Jr. (1974). Breast tumor cell lines from pleural effusions. J Natl Cancer Inst, Vol. 3: 661-674. , Del Bino, G. and Di Fronzo, G. (1991). Interaction between hormone-dependent and hormone-independent human breast cancer cells. Eur J Cancer, Vol. 9: 1154-1157. , Chen, S. and Nie, D. (2009). Regulation of drug resistance by human pregnane X receptor in breast cancer. Cancer Biol Ther, Vol.