By Gerry Melino, David Vaux
This e-book on mobilephone demise includes 29 self-contained, peer-reviewed articles written by way of prime scientists in each one box. It gains evaluate articles aimed toward undergraduates and non-specialists, which current simple details and supply access into the next complicated articles. those complicated articles are written for postgraduate scholars and study employees, containing specified info and key references permitting the reader to enquire a particular quarter in additional intensity. The booklet is a vital source for academic reasons in addition to a reference paintings for skilled researchers within the box. The articles may also be on hand electronically as a part of the acclaimed Encyclopedia of existence Sciences (ELS).Key features:Provides a finished assessment at the learn of programmed telephone death.Edited through leaders within the field.Clearly written and illustrated articles.Full color throughout.A spin-on to the acclaimed reference paintings, the Encyclopedia of existence technology (ELS).Combines introductory details with insurance of the newest discoveries within the field.Features evaluation point articles for complicated scholars or humans new to a subject matter and extra complicated articles for these requiring extra distinct information.Serves as a reference paintings for complicated scholars in addition to researchers during this field.Ideal library buy for technological know-how, scientific, and know-how libraries in academia, govt, and undefined; scientific libraries; networks and consortia overlaying those markets.
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Additional info for Cell Death (Encyclopedia of Life Sciences)
One possible explanation for these observations is provided by the ‘nurse cell model’, which postulates that physiological germ cell death serves a homeostatic function. Indeed, the many nuclei in the distal part of the germline are not only potential gametes, they also function as de facto nurse cells, by contributing to growth of the common syncytium from which oocytes mature. However, while a large number of nuclei in the distal gonad arm is required for optimal oogenesis, only a few cell nuclei are needed to generate the mature oocytes found in the proximal gonad.
1038/ 35003120. Avery L and Horvitz HR (1987) A cell that dies during wildtype C. elegans development can function as a neuron in a ced-3 mutant. Cell 51(6): 1071–1078. Bergamaschi D, Samuels Y, O’Neil NJ et al. (2003) iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human. Nature Genetics 33(2): 162–167. 1038/ ng1070. Chan SL, Yee KS, Tan KM and Yu VC (2000) The Caenorhabditis elegans sex determination protein FEM-1 is a CED-3 substrate that associates with CED-4 and mediates apoptosis in mammalian cells.
Madeo F, Fro¨hlich E, Ligr M et al. (1999) Oxygen stress: a regulator of apoptosis in yeast. Journal of Cell Biology 145: 757–767. Meier P, Finch A and Evan G (2000) Apoptosis in development. Nature 407: 796–801. Nathan C (2008) Metchnikoﬀ’s legacy in 2008. Nature Immunology 9: 695–698. Oberst A, Bender C and Green DR (2008) Living with death: the evolution of the mitochondrial pathway of apoptosis in animals. Cell Death and Diﬀerentiation 15: 1139–1146. Pedersen K, Zavialov AV, Pavlov MY et al.