By Dougald M. Monroe, Maureane Hoffman (auth.), Hau C. Kwaan, David Green (eds.)
Coagulation in melanoma informs doctors operating within the box of melanoma of the pathophysiologic mechanisms of cancer-related thrombosis and bleeding. It presents tips in spotting some of the bleeding and clotting problems linked to melanoma and contains present thoughts for the administration of hemorrhage, and prevention and remedy of thrombosis within the sufferer with malignancy.
This quantity is a worthy addition to the literature on melanoma and coagulation.
"The complicated interface among melanoma and hemostasis is the point of interest of this outstanding textual content. wonderful figures within the box dissect the impression of melanoma on coagulation and coagulation on melanoma. A extensive spectrum of subject matters are lined exploring mechanistic concerns and difficulties of scientific relevance."
Steven T. Rosen, M.D.
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Extra resources for Coagulation in Cancer
6 Role of Thrombin In addition to its well known actions on the coagulation cascade, thrombin is a potent growth factor for mesenchymal cells [51–53], a proangiogenic factor  that stimulates endothelial cell mitogenesis and migration. The cellular effects of thrombin are mediated by the G-protein-coupled seven transmembranespanning protease-activated receptors (PARs)-1, -3 and -4. The unique mode of PAR-1 receptor activation results from cleavage of its N-terminal end which exposes a tethered ligand capable of binding to the second extracellular loop of the receptor.
These and other probable mechanisms for thrombosis in cancer patients have been examined in detail elsewhere [2, 28, 30]. Suffice it to say that the pathogenesis of thrombosis in cancer is complex and most likely involves multiple mechanisms that may differ dramatically from patient to patient. However, until recently, it has been presumed that all of these mechanisms are secondary and have no primary role in the molecular events leading to the development of cancer. 4 Molecular Pathogenesis of Thrombosis in Cancer – Direct Link to Oncogenesis Boccaccio and her colleagues developed a model for human liver carcinoma by targeting activated human MET oncogene to mouse liver with a lentiviral vector and liver-specific promoter .
J Thromb Haemost 2004;2:2107–14. Chapter 3 Activation of Clotting Factors in Cancer Frederick R. 1 Introduction Evidence for ‘‘hypercoagulability’’ is commonly found in patients with cancer and increases the risk of thromboembolism (TE) . While the pathophysiology of TE in cancer is complex, it can be viewed classically as related to abnormalities of Virchow’s triad: stasis of the blood; vascular injury; hypercoagulability (or, as described by Virchow himself, as ‘‘abnormalities of the fixed elements of the blood’’) .