By James B. Caulfield, Sun Ben Tao (auth.), Francis L. Abel M.D., Ph.D., Walter H. Newman Ph.D. (eds.)

These complaints are from the 5th Annual assembly of the yankee element of the overseas Society for center study held at Hilton Head Island, South Carolina, September 21-24, 1983. this system and abstracts have been released within the magazine of Molecular and mobile Cardiology, Vol. 15, complement four, September 1983, educational Press. This Symposium court cases involves 3 sections. part I bargains with the mechanical elements and their i'nfluence on coronary blood move within the common and failing middle. part II is constructed round the zone of vascular soft muscle and the criteria which can keep an eye on it which finally play such a big function within the law of coronary blood move. part III is basically dedicated to the mechanical facets of the functionality of the center in either hypertrophy and failure together with the molecular adjustments within the myocyte, changes in neural keep an eye on, and in inotropic responsiveness of the hypertrophied and failing middle. The editors wish that those 3 parts surround an important physique of recent and ongoing info that might be useful to people who paintings in those parts in addition to those that deal with sufferers with various levels of myocardial failure or with compromised coronary circulations. The editors convey their appreciation to the entire participants and to Ms. Jeri B. McClain for aiding within the association and compiling of this quantity. Francis L. Abel, M. D. , Ph. D. Walter H. Newman, Ph. D.

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Circulation (62): 255, 1980. Gregg DE, Fisher LC: Blood supply to the heart. In: Hamilton WF, Dorn P (eds) Handbook of physiology, Section 2, Circulation. American Physiological Society, Washington, 1963, vol. 2. Gregg DE, Khouri EM, Rayford, CR: Systemic and coronary energetics in the resting unanesthetized dog. Circ Res (16):102-113, 1964. Hammond GL, Austen WG: Drainage patterns of coronary arterial flow as determined from the isolated heart. Am J Physiol (212):1435-1440, 1967. Hess DS, Bache RJ: Transmural right ventricular myocardial blood flow during systole in the awake dog.

14. 15. 16. 17. 18. 19. 20. Sabiston DC, Gregg DE: Effect of cardiac contraction on coronary blood flow. Circulation (15):14-20, 1957. Wiggers CJ: The interplay of coronary vascular resistance and myocardial compression in regulating coronary flow. Circ Res (2): 271-279, 1954. Downey JB, Kirk ES: Inhibition of coronary blood flow by a vascular waterfall mechanism. Circ Res (36):753-760, 1975. Spann JAE, Breuls NPW, Laird JD: Diastolic-systolic coronary flow differences are caused by intramyocardial pump action in the anesthetized dog.

E 200 .... J 120 E ;: II.. C 80 Z o o Il: o .......... •. •. - . . . : . :.... o 20 40 80 80 100 AORTIC PRESSURE (mm Hg) 120 0 40 80 120 180 200 240 HEART RATE ( I min) FIGURE 5. Total, systolic, and diastolic flow versus aortic pressure and heart rate. Total and systolic curves matched by geometric regression on mean values. See text for discussion. The resultant postulated curves are shown by the solid lines in Fig. 5. Since we obtained no data at pressures less than 40 mmHg, they are estimates only.

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