By Cynthia Nau Cornelissen Ph.D.

A must-have for learning crucial suggestions in Microbiology.
Based at the best-selling Lippincott Illustrated reports sequence, Lippincott Illustrated reports Flash playing cards: Microbiology is helping you evaluation, assimilate, and combine necessities of advanced subject material. built for speedy content material absorption, those two hundred high-yield playing cards help path studying and board examination preparation.
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What bacterium produces the exotoxin with this activity? 19 Answer Heat-stable toxin acts via the mechanism shown. Enterotoxigenic Escherichia coli (ETEC) produces the exotoxin with this activity. A + Guanylate cyclase cGMP GTP Secretion of water and ions Heat stable toxin Heat stable toxin produced by ETEC activates guanylate cyclase resulting in an increase in cGMP concentrations and increased secretion of water and ions and to diarrhea. indd 38 Copyright © 2015 Wolters Kluwer 5/2/14 11:18 PM The Microbial World What toxin exerts its activity when the intracellular bacterium producing it is within a phagocytic vesicle, as indicated by the black arrow?

Vibrio cholerae produces the exotoxin with this activity. indd 26 NAD+ G Protein A Cholera toxin Nicotinamide ADPR G Protein Prot ro rot Toxin ADP-ribosylates a G protein of intestinal mucosal cells, resulting in ionic imbalance and loss of water. Copyright © 2015 Wolters Kluwer 5/2/14 11:18 PM The Microbial World What toxin has the mechanism of action shown? What bacterium produces the exotoxin with this activity? 14 Question A Amino acids Protein Prot Pro ro Toxin cleaves host ribosomal RNA, resulting in inhibition of protein synthesis.

Two serious limitations to employing Koch’s postulates to identify disease etiology are (1) the organism must be culturable in the laboratory and (2) the organism must cause disease in an animal other than humans. Sick 1 2 The microorganism must always be found in similarly diseased animals but not in healthy ones. The microorganism must be isolated from a diseased animal and grown in pure culture. Sick 3 4 The isolated microorganism must cause the original disease when inoculated into a susceptible animal.

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