By Gilbert Thompson

Tony Seed, Gilbert Thompson, Jackie Downs and John MacDermot on the book's release in London

This publication brings jointly in a single quantity fifteen Nobel Prize-winning discoveries that experience had the best effect upon clinical technology and the perform of medication throughout the twentieth century and as much as the current time. Its total objective is to enlighten, entertain and stimulate. this can be specifically so should you are concerned with or considering a occupation in scientific examine.

an individual attracted to the details of a selected award or Laureate can receive precise details at the subject via having access to the Nobel Foundation's web site. by contrast, this publication goals to supply a much less formal and extra own view of the technological know-how and scientists concerned, through having in demand teachers write a bankruptcy each one a couple of Nobel Prize-winning discovery of their personal components of curiosity and services.

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The most famous are those of Kansas Professor of Medicine Ralph Major’s patient Billy Leroy in his June 1923 paper in the Journal of the American Medical Association. 8 kg. 16 Even in a world without fax or e-mail, news of the discovery spread rapidly. One reason for this was the more international outlook of medical journals in those days; American, English, French and German journals all reported medical meetings in other countries and printed abstracts of papers from other journals. In Index Medicus in 1922 there were only 19 references to ‘insulin’ or an equivalent term (such as pancreatic extract): 7 each in the Lancet and British Medical Journal and 5 in the Journal of the American Medical Association.

Qxd 11/4/2011 b1268 38 9:17 AM Page 38 Nobel Prizes that Changed Medicine A. V. Hoffbrand over the last two or three decades, much of the research has been into cardiovascular, obstetric and malignant disease. The reaction, methionine synthase, in which methylTHF is converted to THF, and which requires methylcobalamin, results in the methylation of homocysteine to methionine (Fig. 4). Homocysteine levels have been found to be raised in the plasma of patients with folate or vitamin B12 deficiency.

Trans Assoc Am Physicians 1926; 41: 72–75. 23. Minot GR, Murphy WP. Treatment of pernicious anemia by a special diet. JAMA 1926; 87: 470–476. 24. Savage DG, Lindenbaum J. Neurological complications of acquired cobalamin deficiency. Clin Haemat 1995; 8: 657–678. 25. Minot GR, Cohn EJ, Murphy WP et al. Treatment of pernicious anemia with liver extract: effects upon the production of immature and mature red cells. Am J Med Sci 1928; 175: 599–606. 26. Gänsslen M. Ein hochwirksamer injizierbarer leberextrakt.

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