By D. Krewski, D. Wigle, D. B. Clayson, G. R. Howe (auth.), Pierre Band M.D. (eds.)
The id of occupational melanoma possibility elements and of cancer agents within the office is assuming expanding import ance in melanoma epidemiology. This publication, which incorporates the court cases of a symposium held in Vancouver in June 1988, combines overviews via specialists on great issues and methodologic problems with large curiosity in occupational melanoma epidemiology. one of the former are state-of-the-art reports emphasizing contemporary facts and new and leading edge analytic techniques. The sizeable issues comprise dialogue of melanoma dangers from publicity to complicated natural combinations, asbestos and man-made fibers, herbicides, radon, and electromagnetic fields. chance evaluate, publicity overview, and research of occupa tional cohort stories are examples of the methodologic concerns addressed. This booklet presents uncomplicated details and opens views on new components of analysis. In organizing our symposium we have been enormously assisted through Betty Fata and Kim Rust of Venue West convention Ltd. We savour the monetary help got from the next: melanoma regulate organisation of British Columbia Alcan Aluminium Ltd. nationwide well-being examine & improvement application employees' repayment Board of British Columbia Purdue Frederick Inc. Rhone-Poulenc Pharma Inc. London medications Ltd. Ciba-Geigy Canada Ltd. Bristol-Myers Pharmaceutical staff Schering Canada Inc. Hoffmann-La Roche Ltd. Sterling Drug Ltd. Parke-Davis Canada Inc. Beecham Laboratories Pfizer Canada Inc. Roussel Canada Inc.
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7. The kappas were slightly higher for internal-internal comparisons than for internal-external ones. These results indicate a relatively high degree of inter-rater agreement over a range of industries, occupations and time periods of employment. Even though these results lend credibility to the overall validity of this type of retrospective exposure assessment, there is little data in the literature to allow 46 M. Gerin comparisons to be made. Furthermore, the degree of agreement from substance to substance has not been evaluated in these trials.
Industrial and occupagents + radiations ational titles classifications) Hoar et al. S. Agents Job classification Origin Table 1. S. : (1) '0 tTl ::: @ .... n po ::: o· e:- '0 ~ e n on 8S· (1) [3 en en (1) en ;l>- (;l oen e '0 tTl >< (1) ~;- ~ .... oen "g g ::0 44 M. Gerin Subject by Subject Exposure Assessment by Experts in a Large Population-Based Case-Control Study in Montreal Since 1979, a large case-control study of occupational cancer has been under way in Montreal. Only methods of exposure assessment are summarized here, as an example of what could be achieved in population-based hypothesisgenerating studies where experts are asked to evaluate a multiplicity of exposures from questionnaire data.
Table 8 summarizes the statistical power to detect a given risk in the five strategies. By definition, the INT + CHEM strategy, the gold standard, provides greatest power. Power is lost in other strategies because the twofold risk that is assumed in the INT + CHEM strategy is diluted by misclassification, and the 36 1. Siemiatycki Table 8. 05 and n = 2 x 500. The twofold risk is that obtained in the INT + CHEM design. For the other designs, misclassification leads to a lower relative risk that must be detected, and thereby lower power.