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By Douglas Brian Evans, Peter W. T. Pisters, James L. Abbruzzese
The MD Anderson sturdy Tumor Oncology sequence offers state of the art surgery and clinical remedy for particular websites. This quantity, Pancreatic melanoma, addresses epidemiology and molecular biology, inherited syndromes, staging, surgical innovations, multimodality treatment, and rising cures. the person chapters specialise in slim, particular themes to provide a reference paintings of price to these attracted to pancreatic melanoma from a scientific and translational study viewpoint. vital for surgical oncologists and basic surgeons.
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Extra resources for Pancreatic Cancer
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Butera J, Malachovsky M, Rathore R, Safran H. 2. The Molecular Biology of Pancreatic Cancer 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. Novel approaches in development for the treatment of pancreatic cancer. Front Biosci. 1998;3:E226– 229. Hall PA, Hughes CM, Staddon SL, Richman PI, Gullick WJ, Lemoine NR. The c-erb B-2 protooncogene in human pancreatic cancer. J Pathol. 1990;161(3):195–200. Dugan MC, Dergham ST, Kucway R, et al. HER2/neu expression in pancreatic adenocarcinoma: relation to tumor differentiation and survival.
Seventy percent of the point mutations are transitions, with the remainder being transversions. Interestingly, in pancreatic cancers associated with cigarette smoking, inactivation of p53 is more likely to result from transversion point mutations than from transition mutations. 5,56,57 17 p16 p16 is a member of the INK4 family of cyclindependent kinase inhibitors (CKIs), which includes p15 and p19ARF, whose overall function is to inhibit cell cycle progression. 5,58 The INK4 family members are all located within close proximity to each other on chromosome 19p21.
Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell. 1988;53(4):549–554. Friess H, Berberat P, Schilling M, Kunz J, Korc M, Buchler MW. Pancreatic cancer: the potential clinical relevance of alterations in growth factors and their receptors. J Mol Med. 1996;74(1):35–42. Moskaluk CA, Hruban RH, Kern SE. p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma. Cancer Res. 1997;57(11):2140–2143. Tada M, Omata M, Ohto M. Ras gene mutations in intraductal papillary neoplasms of the pancreas.