By Pavel Koldovský, V. G. Allfrey, M. Allgöwer, K. H. Bauer
Tumor particular Transplantation Antigen experiences the theories, equipment, and experimental findings within the box of immunobiology of tumors with specific specialise in the tumor antigen answerable for transplantation resistance. The monograph provides discussions at the tools of induction of antitumor immunity; tools of detection of antitumor immunity; virus-induced tumors; the features of TSTA; tumor development and improvement of immunity; and the theoretical and useful probabilities of the presence of transplantation immunity opposed to tumors in guy. Oncologists, phone biologists, immunobiologists, and scientific researchers will locate the booklet valuable.
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There are various human cancers which actively synthesize particular attribute proteins reminiscent of melanomas, thyroid melanoma and squamous mobile carcinoma. Many melanoma researchers have after all attempted to make use of this particular task as a key for the selective remedy of cancers. some time past for instance, the molecular hybrid compound of DOPA, a substrate of melanin, and nitrogen mustard N-oxide hydrochloride, a ctyotoxic anti-tumor drug, used to be synthesized as Melphalan and used to regard malignant cancer.
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Extra info for Tumor Specific Transplantation Antigen. Recent Results in Cancer Research
Their non-reactivity was more apparent when compared with the effect of cells from donors immunized in the same manner but with much smaller doses (Fig. 5). Non-reactivity of cells from "paralyzed donors" lasted only 3 weeks. 28 Methods o f D e t e c t i o n o f Antitumour I m m u n i t y Thereafter, there was a retardation in growth, and by the 30th day the tumours were twice smaller than those observed in control animals. The break in the original curve is typical of the given experimental system, as has been confirmed in repeated experiments.
APFFEL et al. (1966) showed that a considerable amount of antigenic material was localized in the ascites fluid of the Ehrlich carcinoma, EL 4 leukaemia, S-37 sarcoma and Krebs ascites tumour. BIGGS and EISELEIN (1965) found that the antigenicity of Ehrlich carcinoma ascites fluid resided within filterable particles. The antigen could be effectively removed by filtration through filters of 100 ιημ porosity. The particles were proved to be a leukeumogenic virus even by biological tests. There are experimental data supporting the hypothesis that immune cells damaging the target cells are also destroyed (CUDKOWICZ and COSGROVE, 1960).
26 Methods of D e t e c t i o n o f A n t i t u m o u r I m m u n i t y Furthermore, no correlation between the presence of CF antibodies and resistance to the tumour has been demonstrated for Rous sarcoma (serving as an example of tumours induced by RNA viruses). The question of the relationship between the specific antigen in leukaemias producing the mature, infectious virus and viral antigens is more difficult. An ingenious approach to this problem was made by PASTERNAK (in press) with Graffi leukaemia; he found that Landschütz sarcoma contained and produced the Graffi virus without any other alterations.