By Michael Baum, Craig Henderson

Every one quantity within the vintage Papers sequence offers as much as 2 hundred of crucial papers released in a specific strong point. The papers were conscientiously compiled, no longer in simple terms for his or her ancient value but additionally for his or her modern relevance. during this quantity, vintage Papers in Breast illness, a staff of specialists stocks their adventure in discovering, diagnosing and treating breast sickness. The observation, regularly insightful and simple, levels from idea to perform, from actual to mental. for instance, experts speak about molecular biology and endocrinology in addition to the mental facets of the affliction and steps clinicians can take to control ache.

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Journal of Clinical Oncology 1986; 4:1772– 1779. Key message Time with toxicity or symptoms should be discounted when comparing treatments. Why it’s important This paper provided a method for integrating quality of life measures into the overall evaluation of a treatment. Weight factors are unavoidably subjective, but for any given set of weights a trade-off analysis could be done to determine under what conditions one treatment is superior to another. If one treatment is superior for all weights, then It is clearly better; whereas if not, subjective decisions about trade-offs between time with symptoms and increased overall survival need to be made.

3. The late side-effects of radiotherapy were established. Weaknesses 1. Detailed causes of late mortality were not given. ) 2. Long-term effects always relate to treatments used many years ago, and may not be relevant to new treatments. This is especially important for breast cancer, where radiotherapy, surgery and adjuvant therapy have all changed markedly. Relevance Overviews have become the standard for evaluating new treatments subject to trial by several groups. With the advent of breast conserving surgery, radiotherapy is now being used more for good prognosis patients, where late mortality from cardiovascular disease is a particularly serious side effect.

Relevance Beware of all conclusions based on studies comparing groups that are defined by any criteria other than randomization. CHAPTER 2 Biostatistics JACK CUZICK Introduction A choice of papers that highlights pivotal biostatistical contributions to breast cancer is particularly difficult, not only because of the scope of ‘biostatistics’ but also its intrinsic interaction with the subject under study. At one extreme, relevant major advances in theoretical statistics have a much wider applicability than breast cancer alone, whereas at the other extreme important applied statistical work generally makes a major contribution to the subject matter, so that a particular paper is also appropriate to another chapter in this book.

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