Download Drug Discovery: A History by Walter Sneader PDF
By Walter Sneader
Written via a number one authority with an exceptional acceptance and talent for writing an outstanding narrative, Drug Discovery: A History is a miles cry from easily a listing of chemical buildings.
This vigorous new textual content considers the origins, improvement and background of medications that generate excessive media curiosity and feature a massive social and fiscal influence on society.
Set inside of a large old, social and cultural context, it offers accelerated assurance of pre-twentieth century medicinal drugs, the massive advances made within the 20th century and the most recent advancements in drug learn.
Hallmark features:
- Up-to-the-minute info in drug research
- Vignettes of exact and strange info, and anecdotes
- Discusses drug prototypes from all sources
- More accomplished than different volumes on heritage of drug discovery
From the reviews:
"...an first-class bibliographic source for these attracted to the historical past papers that function the basis for discovery of particular drug entities." magazine OF scientific CHEMISTRY, June 2006
"...a very accomplished assessment of drug improvement. it's going to be at the shelf on any aspiring pharmacist, medicinal chemist, or individual drawn to the background of healing agents." magazine OF CHEMICAL schooling, February 2006
"...a very readable and heavily researched book..." CHEMISTRY & undefined, October 2005
Content:
Chapter 1 creation (pages 1–7):
Chapter 2 The Prehistoric interval (pages 6–11):
Chapter three Pre?Hellenic Civilisations (pages 12–17):
Chapter four Greece and Rome (pages 18–23):
Chapter five The Arab global (pages 24–31):
Chapter 6 Herbals (pages 32–40):
Chapter 7 Chemical medications (pages 41–73):
Chapter eight Systematic drugs (pages 74–87):
Chapter nine Alkaloids (pages 88–105):
Chapter 10 Non?Alkaloidal Plant items (pages 106–114):
Chapter eleven Plant Product Analogues and Compounds Derived from Them (pages 115–150):
Chapter 12 The Origins of Hormone remedy (pages 151–154):
Chapter thirteen Neurohormones (pages 155–163):
Chapter 14 Peptide Hormones (pages 164–172):
Chapter 15 intercourse Hormones (pages 173–178):
Chapter sixteen Adrenal Cortex Hormones (pages 179–184):
Chapter 17 Prostaglandins (pages 185–187):
Chapter 18 Hormone Analogues (pages 188–225):
Chapter 19 supplementations (pages 226–247):
Chapter 20 Antimetabolites (pages 248–268):
Chapter 21 Blood and organic items (pages 269–286):
Chapter 22 Antibiotics (pages 287–318):
Chapter 23 Antibiotic Analogues (pages 319–340):
Chapter 24 Pharmacodynamic brokers from Micro?Organisms (pages 341–348):
Chapter 25 Analogues of Pharmacodynamic brokers from Fungi (pages 349–354):
Chapter 26 the 1st man made medicines and Their Analogues (pages 355–374):
Chapter 27 medications Originating from the Screening of Dyes (pages 375–402):
Chapter 28 medicinal drugs Originating from the Screening of natural chemical substances (pages 403–431):
Chapter 29 medicinal drugs came upon via Serendipitous Observations regarding people (pages 432–437):
Chapter 30 medicinal drugs found via Serendipity within the Laboratory (pages 438–445):
Chapter 31 Concluding comments (pages 446–447):
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Extra info for Drug Discovery: A History
Sample text
The remaining parts were published in 1571 and 1574 and were so enthusiastically received that expanded editions and numerous translations soon appeared. An English translation was printed in 1577 under the title Joyfull Newes Out of the Newe Founde Worlde. The complete work mentioned products such as balsam, china root, coca, guaiac, jalap, passion flower, guava, sarsaparilla, sunflower and tobacco, all of which soon appeared in the premises of apothecaries throughout the continent. Monardes was not the first to recommend guaic, a resin exuded from the heartwood of the small West Indian tree known now as Guaiacum officinale L.
Before long, this revealed to them the efficacy of the bark in relieving the disease. Jarcho also cited the 2nd edition of the Opera Medica by the chief physician to Philip IV of Spain, Pedro Miguel de Heredia, who died about 1661. This 2nd edition of his book, which was not published until 1689, described the use of powdered ‘quarango’ bark by the Indians of Quito after exposure to coldness and how the Jesuits successfully exploited this in treating malaria. The details given in this account are similar to those published by Caldera de Heredia, Herbals _______________________________________________________________________________________________________ 35 but the author goes on to say that in Madrid he had been shown the bark by the son of the late Count of Cinchon.
CINCHONA BARK Two genuinely efficacious herbs from South America were introduced into Europe in the sixteenth century. The first of these was cinchona bark, Cinchona officinalis L. There are two accounts of how it was introduced into Europe. A fictitious version was included in a book known as the Anastasis Corticis Peruviae, published in 1663 by a Genoese physician called Sebastianus Badus. He claimed that 30 or 40 years earlier, during an epidemic in the city of Lima in Peru, the bark had cured the Countess of Cinchon, wife of the viceroy of the province, of a severe attack of tertian fever (malaria).