By A. Moscona Alberto Monroy
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Additional resources for Gene Activity and Communication in Differentiating Cell Populations
The newborn spleen fragments were exposed to a short pulse of the antigen, DNP-PLL, for 30 minutes ( Bernstein and Globerson, 1973a), washed in phosphate buffered saline, and overlayed with adult allogeneic spleen cells. It was found that these cultures showed an enhanced response to DNP, yet the antibodies produced were of the 19 S class only (Globerson, unpublished). It appears, therefore, that the factors released from T cells enhance the IgM response. Whether or not the T-cell activity in induction of IgG antibodies is also due to the release of nonspecific factors remains an open question.
1969). J. Cell Biol. 41, 188. Britton, S. (1972). Scand. J. Immunol. 1, 89. , Mitchison, N. , and Pitt-Rivers, R. (1966). Immunology 10, 481. , and Levey, R. H. (1972). Cell. Immunol. 4, 305. Bumet, M. (1959). ” Cambridge Univ. Press, London and New York. Bussard, A. , and Lurie, M. (1967). J. E x p . Med. 125, 873. Bussard, A. , Nossal, G. J. , Mazie, J. , and Lewis, H. (1970). J. E x p . Med. 131, 917. , and Ada, G. L. (1969). Immunology 17, 503. Chu, M. , and Fischer, G. A. (1962). Biochem.
And Holtzer, H. (1969). J. Cell Biol. 41, 188. Britton, S. (1972). Scand. J. Immunol. 1, 89. , Mitchison, N. , and Pitt-Rivers, R. (1966). Immunology 10, 481. , and Levey, R. H. (1972). Cell. Immunol. 4, 305. Bumet, M. (1959). ” Cambridge Univ. Press, London and New York. Bussard, A. , and Lurie, M. (1967). J. E x p . Med. 125, 873. Bussard, A. , Nossal, G. J. , Mazie, J. , and Lewis, H. (1970). J. E x p . Med. 131, 917. , and Ada, G. L. (1969). Immunology 17, 503. Chu, M. , and Fischer, G. A.