By Andrew D. Rape, Wei-Hui Guo, Yu-Li Wang (auth.), A. Wagoner Johnson, Brendan A.C. Harley (eds.)

Mechanobiology of Cell-Cell and Cell-Matrix Interactions makes a speciality of characterization and modeling of interactions among cells and their neighborhood extracellular atmosphere, exploring how those interactions may well mediate cellphone habit. experiences of cell-matrix interactions depend upon integrating engineering, biology, and imaging disciplines. fresh advances within the box have began to solve our knowing of the way cells assemble info from their surrounding setting, and the way they interrogate such info throughout the phone destiny selection making procedure. these kind of new advancements are mentioned during this quantity, and the booklet also:

  • Provides an exam of the mechanobiology of cell-matrix interactions
  • Discusses the rising quarter of cooperative habit of cells, in addition to present equipment for probing phone mechanics
  • Explores the mechano-pathology of melanoma and disease

Other themes comprise adhesive and integrin-ligand interactions, extracellular impacts on mobile biology and behaviour and the mechanobiology of pathological strategies, between others. Mechanobiology of Cell-Matrix Interactions is a perfect ebook for researchers and engineers operating in biomedical engineering and comparable fields.

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Extra resources for Mechanobiology of Cell-Cell and Cell-Matrix Interactions

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Ryan, PL, Foty, RA, Kohn, J, Steinberg, MS (2001) Tissue spreading on implantable substrates is a competitive outcome of cell-cell vs. cell-substratum adhesivity. Proc Natl Acad Sci U S A 98:4323 43. Pittet, P, Lee, K, Kulik, AJ, Meister, JJ, Hinz, B (2008) Fibrogenic fibroblasts increase intercellular adhesion strength by reinforcing individual OB-cadherin bonds. J Cell Sci 121:877–86 44. Wang, N, Tytell, JD, Ingber, DE (2009) Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus.

Matrix elasticity also clearly has significant effects on stem cell fate in 3D culture, but there are a greater number of potential underlying mechanisms in this type of culture system. First: in 3D, because cells are exposed to all the components of the crosslinking reaction used to make hydrogels, changes in cell behavior may result from the small molecules used to control matrix elasticity. Alternatively, as crosslinks are added to the matrix, the diffusive transport of instructive morphogens may be substantially altered [53].

References 1. Tenney, RM, Discher, DE (2009) Stem cells, microenvironment mechanics, and growth factor activation. Curr Opin Cell Biol 21:630–5 2. Vogel, V, Sheetz, MP (2009) Cell fate regulation by coupling mechanical cycles to biochemical signaling pathways. Curr Opin Cell Biol 21:38–46 3. Mammoto, T, Ingber, DE (2010) Mechanical control of tissue and organ development. Development 137:1407–20 4. Keese, CR, Giaever, I (1991) Substrate mechanics and cell spreading. Exp Cell Res 195:528–32 5. Weiss, P, Garber, B (1952) Shape and movement of mesenchyme cells as functions of the physical structure of the medium: contributions to a quantitative morphology.

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