By MD J.Donald Capra, Maurizio Zanetti, Donald J. Capra

Meant for experts in B telephone immunology, investigating such subject matters as stream of a monoclonal antibody from the laboratory into the health center, the sphere of Fc receptors and the effect of monoclonal antibodies on prognosis and therapy of human

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FcR are ubiquitous antigen receptors with an adaptive specificity. II. NOMENCLATURE OF FcR FcR nomenclature is particularly complicated and unappealing (Table 1). The reason is that it results from the sedimentation of successive layers of knowledge which accumulated with time, as studies on FcR progressed. One way to penetrate this nomenclature may therefore be to briefly survey FcR history. For didactic purposes, one can distinguish, after the first functional era mentioned above, four successive periods, during which FcR were viewed as different entities through the experimental tools available.

As stressed earlier, a single FcR can be expressed by different cell types and a given cell can express several FcR. As described below, they can be up- or downregulated by environmental stimuli. It follows that FcR are versatile and not always reliable markers. C. FcR as Glycoproteins When coupled to sepharose and used as immunoadsorbents, immunoglobulins and monoclonal antibodies permitted to purify high- and low-affinity FcR from [125I]-labeled cells and to analyze them by electrophoresis. FcR appeared as highly glycosylated, heterogeneous molecules.

Blood 83, 435–445. , and Winter, G. (1988). Reshaping human antibodies for therapy. Nature 332, 323–327. , and Pichlmayr, R. (1994). Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes’ C colorectal carcincoma. The Lancet 343, 1177–1183. C. (1994). Humanization of murine monoclonal antibodies through variable domain resurfacing. PNAS 91, 969–973. C. (1996). A comparison of two murine monoclonal antibodies humanized by CDR-grafting and variable domain resurfacing. Protein Eng.

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